Unfortunately the “experts ”announce the cases, the intubated, the deaths, as well as the measures they decide and impose.
But people are unaware of the efforts of Molecular Biologists and Immunologists to find effective treatments for Covid-19., because lies are bad… whatever vaccines are created, viruses will continue to evolve and mutate… και πάντα κάποιοι θα νοσούν.
What about medicines that will help sick citizens recover;
The research team of the Department of Molecular Biology at the University of Göttingen, in collaboration with three other university research centers studied possible treatments for COVID-19 infection, including some that have already been approved by the US FDA for the treatment of other diseases, which, however, also find application in the infection that is currently afflicting the planet.
The team, whose findings have been published in the most prestigious scientific journals, εξέτασε χιλιάδες υπάρχοντα φάρμακα και διάφορα άλλα μόρια, in their ability to inhibit the proliferation of the SARS-CoV2 virus causing COVID-19 infection. Unlike many previous studies, Various molecules for anti-Quranic activity in a variety of cell types were tested, and human cells of the respiratory system, που είναι παρόμοια με εκείνα που κυρίως επηρεάζονται στη λοίμωξη COVID-19.
Drugs found to reduce SARS-CoV-2 proliferation in respiratory cells, some, as mentioned, have already been approved by the US FDA: the drug cyclosporine against graft rejection, the anti-cancer drug dacomitinib and the antibiotic salinomycin. These need to be tested quickly and on a large scale, to volunteers, as well as in patients with COVID-19.
The research also shed light on key pathways and viral processes used by the coronavirus to infect different cells and found that the antiviral drug remdesivir, appears to work against the virus in respiratory cells, something that hydroxychloroquine never did, which was so advertised.
Examined above 3.000 compounds, including approx 1.000 FDA-approved medicines and more than 2.000 molecules, which have shown activity against defined biological targets. They were then tested for their ability to significantly inhibit SARS-CoV-2 replication in infected cells., but without causing great toxicity.
Because SARS-CoV-2 is primarily a respiratory virus that causes infections of the airways cells, researchers looked for a type of respiratory cell that could be experimentally infected with the virus. Αναγνωρίζοντας διαφορετικά σύνολα φαρμάκων που λειτουργούν σε διαφορετικούς τύπους κυττάρων, The researchers also shed light on the mechanisms used by SARS-CoV-2 to enter cells.. The findings show that in the kidneys and liver cells, the virus uses a mechanism that can be disrupted, for example, from hydroxychloroquine. However, the virus appears to use a different mechanism in the respiratory cells, thus explaining the lack of success of hydroxychloroquine in these cells.
Probably, as it appears, he is going to be late, ή δεν θα υπάρξει ποτέ μια τέλεια θεραπεία για τη λοίμωξη COVID-19 – but the right medicines for the right patients can in any case help save many lives.
After treatment with SARS-CoV-2 virus for more than a year, Doctors are still facing the same reality that existed months ago: Δεν υπάρχουν γρήγορες και εύκολες λύσεις για τη θεραπεία της λοίμωξης COVID-19 -δυστυχώς, science has no magic wands.
Cures for COVID-19 infection have come after scientific studies and research on combinations of drugs originally developed to fight other viruses that have been shown to be safe and relatively effective in treating the symptoms of the disease., such as steroids used to fight severe inflammation.
But in recent months, Clinical trials have shown many additional drugs that could be included in COVID-19 tools. By themselves, each of these treatments offers a relatively small benefit. But the combinations between them have completely different and more dynamic results.
Currently, Only two drugs are widely agreed to be effective against COVID-19. The first is the expensive antiviral drug remdesivir, which reduces hospital stay by impeding the virus' ability to reproduce. The other, the cheap steroid dexamethasone, is the only drug confirmed in clinical trials to reduce the risk of death in severe COVID-19 patients.
For sure, steroids are proving useful, but researchers are approaching additional treatments that are safe and effective. Of the dozens of drugs, the immunomodulatory drug tocilizumab, που αμβλύνει την καταστροφική φλεγμονή που εμφανίζεται κατά τη διάρκεια της λοίμωξης Covid-19, και ένα αντίσωμα που χρησιμοποιείται σήμερα για τη θεραπεία της ρευματοειδούς αρθρίτιδας θα μπορούσε να βοηθήσει -η δεξαμεθαζόνη.
However, work in different ways. Dexamethasone reduces swelling, having anti-inflammatory action, while Tocilizumab suppresses a cellular receptor that may play an important role in cytokine storms, leading to a destructive inflammatory reaction.
Previous trials with tocilizumab have not yielded significant benefits. Nevertheless, lately, two large, Randomized studies have found that the drug also dramatically reduces the risk of death in hospital patients with COVID-19.
A few months ago, after extensive scientific studies, ανακοινώθηκαν τα αποτελέσματα για το φάρμακο sarilumab -τα αποτελέσματα έδειξαν ότι οι ασθενείς σε κρίσιμη κατάσταση λόγω COVID-19, who took the drug were less likely to need a ventilator and survived than patients who did not.
In a similar study, in patients receiving tocilizumab, the relative risk of death from COVID-19 was reduced by approximately 25% and the chances of being discharged from the hospital increased by approximately 30%, compared with patients who did not receive the drug.
Another drug commonly used to treat rheumatoid arthritis has raised reasonable hopes.. Researchers recommend the use of bariticinib with remdesivir in patients with severe COVID-19 infection., they can not take steroids like dexamethasone, due to allergies or other medical conditions. Average, the addition of this drug reduces the recovery times of patients by strengthening the immune system, σε σχέση με τη λήψη μόνο του remdesivir.
Treatment guidelines are also changing for plasma use by patients who have recovered, which is rich in antibodies and its administration to sick patients - now the administration of this plasma, administered only if its antibody content is high, because as it turned out, plasma with a low number of antibodies does not contribute effectively to treatment. Some researchers argue, πως η χορήγηση πλάσματος σε νοσοκομειακούς ασθενείς με COVID-19 πρέπει να χορηγείται σχετικά νωρίς κατά τη διάρκεια της νόσου και πριν οι επιπλοκές οδηγήσουν τις προσπάθειες θεραπείας σε αχαρτογράφητα νερά.
Current clinical trials continue to test both known and new drugs for their effectiveness against COVID-19 infection.. But it is still too early for substantiated conclusions! A promising treatment includes anticoagulants, such as heparin, which could potentially help reduce the risk of blood clots forming, που σχετίζονται με επιπλοκές της λοίμωξης COVID-19 και να βοηθήσουν στη μη επιδείνωση της κλινική λες κατάστασης των ασθενών.
The anti-inflammatory drug colchicine on the other, which is widely used to treat gout and certain heart conditions, δείχνει να έχει καλά αποτελέσματα μετά από συστηματική χορήγηση -η κολχικίνη βοηθά στη μείωση του συνδυασμένου κινδύνου νοσηλείας ή θανάτου κατά περίπου 28% compared with patients who did not take this medicine. However, Many clinicians still view colchicine with some healthy skepticism. The trial had a low overall mortality and morbidity rate, which means that any death or hospitalization could have a profound effect on the results of the study. From the 4.488 registered patients, only 235 ended up in the hospital or died, included 104 who received colchicine and 131 who did not take the medicine. However, the clinical trial is expanding, για να δοκιμάσει την κολχικίνη, as well as aspirin, the baricitinib and antibody cocktail used to treat US President Donald Trump in his late twenties 2020.
Experts stress that, short term, however, The greatest benefit in reducing COVID-19 mortality will not come from treatment that does not yet exist in the physicians' arsenal., but it will come at least for now, from vaccination. All currently approved vaccines are very effective in preventing life-threatening COVID-19 cases.
The virus adapts to us, but fortunately, adapted to him and the science that deciphers the methods… άμυνάς του, in order to prevent it from multiplying!
Citizens have also realized, how to achieve the shielding of their immune system in relation to dangerous infections, it is necessary for them to strictly adhere to the means of self-protection and to apply some simple things, thinking Orthomolecularly!
To apply Mediterranean-Orthomolecular Diet, to consume plenty of good quality water that hydrates the body, offering him the necessary trace elements and minerals and which has a deterrent effect on blood clots,.., Take increased amounts of naturally occurring vitamin-immune C with zinc, as well as natural nutritional preparations containing 30 Absolutely essential nutrients that the body needs as “fuel oil", for its daily balanced function and for the activation of its own defense mechanisms for the causal self-healing.
Vaccines and drugs, they certainly do their job successfully, as long as we do our part to support them…
We still have a long way to go, until we untangle.
*Mr.. Θοδωρής Γιάνναρος είναι Μοριακός Βιολόγος-Γενετιστής