The largest and most comprehensive analysis of the relationship between aspirin and gastrointestinal cancers to date, published in the prestigious Annals of Oncology finds a reduction in the risk of these cancers between 22% and 38%
Η ασπιρίνη σχετίζεται εδώ και χρόνια με κάποια μείωση του κινδύνου εμφάνισης αρκετών καρκίνων του πεπτικού συστήματος, including some very serious ones, such as pancreatic and liver cancers. Now, this aggregate analysis examined data from 113 observational studies examining cancers in the general population and which were published up to 2019, of which 45 they involved bowel cancer and included 156.000 incidents. In addition to bowel cancer, the cancers that were investigated included those of the brain and throat, of the esophagus, of the stomach, but also tumors in the liver, gallbladder and pancreas.
Investigators, με επικεφαλής τη Cristinaρ Cristina Bosetti (PhD), head of the Cancer Epidemiology Unit at the Mario Negri Oncology Department in Milan, found that regular use of aspirin, defined as taking at least one or two tablets a week, was associated with a significant reduction in the risk of developing most of these tumors. Specifically, aspirin use was associated with 27% less risk of bowel cancer, 33% reduced risk of esophageal cancer, 36% reduced risk of stomach cancer, 38% reduced risk of liver-school cancer (five studies) and 22% pancreatic cancer (15 studies).
Στην έρευνα επισημαίνεται ότι αν η τακτική χρήση ασπιρίνης στην ηλικιακή ομάδα άνω των 50 years increase by 25% in 50% thousands of deaths could be prevented each year from bowel cancer, of the esophagus, of the stomach and pancreas.
Of course, further research is needed to support these findings, especially because the positive results were associated with high doses of aspirin, over 325mg per day. As mentioned in the study, "Our findings on bowel cancer support the idea that higher doses of aspirin are associated with a greater reduction in the risk of the disease.". However, the choice of dose should also take into account the potential risk of bleeding in the stomach, which increases with large doses of aspirin.
Certainly, taking aspirin to prevent bowel cancer or any other cancer, should only be done in consultation with a physician, who can take into account the medical profile of each individual. This includes factors such as gender, the age, family history etc..